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Nandrolone Phenylpropionate

Nandrolone phenylpropionate is a potent injectable anabolic steroid similar to Deca-Durabolin, with the key distinction being the duration of nandrolone release into the bloodstream. Nandrolone decanoate has a prolonged release effect that lasts about 3 weeks, while nandrolone phenylpropionate offers a quicker action, remaining effective for roughly a week. Consequently, Deca-Durabolin can be administered every 2 to 3 weeks, whereas nandrolone phenylpropionate typically requires injections every few days to weekly. Athletes and bodybuilders appreciate both for enhancing strength and promoting lean muscle gains with few estrogenic or androgenic effects.

Structural Characteristics

Nandrolone phenylpropionate features a propionic phenyl ester attached to the 17-beta hydroxyl group, making it less polar than free steroids and promoting slower absorption. When introduced into the bloodstream, this ester is removed, yielding active nandrolone. The compound induces a rapid uptick in nandrolone levels 24-48 hours post-injection, dropping to baseline within a week.

Side Effects (Estrogenic)

This anabolic steroid exhibits a minimal propensity for estrogen conversion, estimated at 20% that of testosterone. Although nandrolone can convert to estradiol in the liver, it is less likely to do so in fat tissues, reducing estrogen-related side effects. However, elevated estrogen can lead to side effects like water retention and gynecomastia at higher doses. Anti-estrogens such as clomiphene citrate or tamoxifen citrate may be necessary if estrogenic side effects occur, alongside aromatase inhibitors like Arimidex for more effective control, albeit at a higher cost.

Additionally, nandrolone possesses some progestin activity. Its structure allows it to bind effectively to progesterone receptors, resulting in effects similar to estrogen, such as negative feedback on testosterone synthesis and increased fat storage. The synergy between these hormones can lead to gynecomastia even without elevated estrogen. An anti-estrogen may effectively moderate this condition.

Side Effects (Androgenic)

Despite its anabolic classification, nandrolone can still present androgenic side effects, particularly at elevated dosages, such as oily skin, acne, and increased body/facial hair. Women must also be wary of potential virilizing effects including voice deepening and clitoral enlargement. Nandrolone’s relatively low androgenic activity means that users can tolerate higher doses with fewer strong androgenic responses compared to testosterone. However, it can still suppress libido when not paired with another androgen during use.

Side Effects (Hepatotoxicity)

Nandrolone, not being c-17 alpha alkylated, is not associated with hepatotoxic effects in healthy individuals, indicating low liver toxicity risk.

Side Effects (Cardiovascular)

The impact of anabolic steroids on cholesterol can be adverse, often lowering HDL and raising LDL levels, which may increase the risk of arteriosclerosis. Administration of nandrolone decanoate at 600mg weekly for 10 weeks has shown a 26% drop in HDL cholesterol, a figure even higher than that seen with testosterone enanthate. Nandrolone decanoate typically affects serum lipids less than c-17 alpha alkylated steroids, yet it may still elevate blood pressure and triglycerides, raising cardiovascular disease risk.

Side Effects (Testosterone Suppression)

All anabolic steroids capable of promoting muscle growth will reduce endogenous testosterone production. Studies demonstrate that 100mg weekly of nandrolone decanoate can cut testosterone levels by about 57%; at 300mg, this reduction climbs to 70%. The progestational activity of nandrolone contributes significantly to this suppression, which may persist even with lower estrogen conversion. Recovery to normal testosterone levels can take 2-6 months post-therapy; however, steroid abuse can lead to prolonged hormonal issues requiring medical assistance.

Administration (Men)

For general anabolic effects, initial guidelines suggest a weekly dosage of 25-50mg for 12 weeks. Performance enhancement typically entails 200-400mg weekly, administered over cycles of 8-12 weeks. Because of the quick-release nature of the phenylpropionate ester, this dosage is generally divided into two separate applications each week.

Administration (Women)

General guidelines also recommend a starting dosage of 25-50mg per week for 12 weeks. For enhancement purposes, 50mg weekly via a single injection across a 4-6 week cycle is commonly used. Higher dosages or extended durations may lead to androgenic side effects and should be approached with caution. If virilization symptoms arise, discontinuation of nandrolone phenylpropionate is advisable to prevent permanent changes.