Euro-Pharmacies Nandrolone Phenylpropionate 10 ml vial (100 mg/ml) EXPIRATION

Nandrolone Phenylpropionate

Nandrolone phenylpropionate, an injectable anabolic steroid, closely resembles Deca-Durabolin in benefits but differs significantly in action duration. While nandrolone decanoate allows for sustained release over three weeks, nandrolone phenylpropionate acts for roughly a week, necessitating more frequent injections, usually every few days to weekly. Both compounds are popular among athletes and bodybuilders for enhancing strength and promoting lean muscle gains with minimal estrogenic or androgenic side effects.

Structural Characteristics

Nandrolone decanoate features a modified nandrolone structure with a propionic phenyl ester at the 17-beta hydroxyl group. The esterification process results in slower absorption, increasing the period of therapeutic effect and allowing for less frequent dosing. Nandrolone phenylpropionate, however, delivers a quick surge in nandrolone levels within 24 to 48 hours after intramuscular injection, tapering off within a week.

Side Effects (Estrogenic)

Nandrolone exhibits minimal estrogen conversion, roughly 20% of that associated with testosterone, limiting estrogen-related side effects. Nonetheless, elevated estrogen from higher doses may lead to water retention, body fat gain, and gynecomastia. Anti-estrogens, such as clomiphene or tamoxifen citrate, may help mitigate these effects, though aromatase inhibitors like Arimidex (anastrozole) can be more efficient but also more costly and potentially detrimental to blood lipid levels.

Moreover, nandrolone displays some progestin activity, potentially causing side effects akin to those from estrogen, including testosterone production suppression and increased fat storage. Given the synergistic relationship between progestins and estrogens, gynecomastia may occur with progestins without high estrogen levels. Correct application of anti-estrogens may effectively reduce such incidence.

Side Effects (Androgenic)

Despite its anabolic classification, nandrolone can still trigger androgenic side effects, particularly at greater doses, leading to symptoms like oily skin, acne, and increased body and facial hair growth. Women may experience virilization effects, including voice deepening and menstrual irregularities. However, nandrolone’s lower androgenic activity relative to its anabolic effects means stronger androgenic reactions are less common than with more potent agents like testosterone. It’s crucial to note that nandrolone can diminish libido in men, particularly when used without an accompanying androgen.

In androgen-sensitive tissues such as the scalp and prostate, nandrolone’s relative androgenicity diminishes via its conversion to dihydronandrolone (DHN) by the 5-alpha reductase enzyme. Concurrent use of a 5-alpha reductase inhibitor like finasteride may reduce nandrolone’s action, potentially increasing androgenic side effects.

Side Effects (Hepatotoxicity)

Due to the lack of c-17 alpha alkylation, nandrolone is not associated with hepatotoxicity in healthy individuals, making liver damage unlikely.

Side Effects (Cardiovascular)

Anabolic and androgenic steroids can adversely affect serum cholesterol levels, notably reducing HDL (good) cholesterol and elevating LDL (bad) cholesterol, potentially increasing the risk of arteriosclerosis. Research indicates that administering 600mg of nandrolone decanoate weekly over ten weeks results in a 26% decrease in HDL. Notably, nandrolone may exhibit a milder impact on serum lipid levels compared to c-17 alpha alkylated steroids, but it could still elevate blood pressure and triglyceride levels while increasing the risk of cardiovascular issues.

Side Effects (Testosterone Suppression)

All anabolic and androgenic steroids tend to suppress endogenous testosterone production. A study administering 100mg of nandrolone decanoate weekly over six weeks revealed an approximately 57% reduction in serum testosterone, which rose to 70% at 300mg weekly. The progestational activity of nandrolone significantly contributes to this suppression. Testosterone levels generally normalize within 2 to 6 months post-therapy, although prolonged use may lead to hypogonadotropic hypogonadism, requiring medical intervention.

Administration (Men)

For anabolic purposes, initial guidelines suggest 25 to 50mg weekly for 12 weeks. Commonly, physique- or performance-oriented dosages range from 200 to 400mg weekly, typically administered in cycles of 8 to 12 weeks, divided into two doses per week due to the rapid-action characteristics of the phenylpropionate ester.

Administration (Women)

Recommended dosages for women follow similar guidelines of 25 to 50mg weekly for 12 weeks. However, for performance enhancement, a single injection of 50mg weekly for cycles of 4 to 6 weeks is standard. Higher dosages are discouraged to mitigate androgenic symptoms, as women can still face virilization effects even at low doses. Immediate discontinuation is advised if virilization symptoms arise to prevent permanent changes.