Euro-Pharmacies T3 bag 50 tabs (50 mcg/tab)

Liothyronine – Cytomel

Thyroid hormones are essential for bodily functions, naturally produced within the body, yet synthetic variants are commonly manufactured by pharmaceutical companies. The primary thyroid hormones are T4, or levothyroxine, and T3, known as liothyronine, both synthesized and stored in the thyroid gland.

Pharmaceutical-grade thyroid hormones are derived from two sources: animal thyroid glands (bovine or ovine) or synthesized in labs. In the US, the iodine content in thyroid preparations is strictly regulated.

Cytomel (liothyronine sodium) is available in tablet form and as a naturally occurring thyroid hormone salt. Notably, T3 is significantly more potent than T4.

Pharmacology

While the precise mechanism through which thyroid hormones operate remains unclear, their influence triggers numerous biochemical pathways in the body. Predominantly, these hormones boost individual energy levels by enhancing the utilization of carbohydrates, lipids, and proteins and by increasing oxygen consumption. Consequently, those who take thyroid hormones often experience a higher basal metabolic rate, impacting nearly every organ system, including the brain.

Dosage

Thyroid hormones are readily absorbed into the bloodstream, with effects manifesting rapidly within hours; however, peak activity may require several days. These hormones persist in the system for a few days due to their binding to albumin in the blood, which shields them from liver metabolism.

• Replacement therapy in hypothyroid patients
• Post-thyroidectomy replacement therapy
• Treatment for goiters and thyroid nodules
• Diagnostic agent in suppression tests for hyperthyroidism
• Alternative for those allergic to pork or beef thyroid

Bodybuilders and Weight Loss

For years, athletes have misused thyroid hormones like Cytomel to facilitate weight loss. The ability of thyroid hormones to promote fat and carbohydrate oxidation drives many to leverage its effects for weight management and enhanced athletic performance.

Cytomel is often administered orally over a 4-6 week cycle, ceasing usage one week prior to competition. This approach reportedly contributes to weight loss and increased energy levels. However, athletes commonly combine this with various other supplements, complicating the matter.

Online sources often recommend starting with a dosage of 25 mcg/day, increasing by 5-10 mcg/day. Generally, a maximum of 100 mcg/day is advised without triggering side effects. Anecdotal evidence suggests 6-12 weeks for effective weight loss, but users must be wary as cessation may result in thyroid insufficiency.

Signs and Symptoms

Excessive intake of thyroid hormones can lead to various side effects, including:

• Headaches
• Mood alterations (irritability, nervousness, anxiety)
• Increased sweating
• Cardiac arrhythmias
• Palpitations
• Chest pain
• Diarrhea
• Menstrual irregularities
• Worsening heart failure
• Shock

Severe overdoses can trigger symptoms akin to thyroid storm, and long-term excessive doses may manifest as hyperthyroidism.

Contraindications

Thyroid hormones are typically contraindicated in untreated adrenal insufficiency, thyrotoxicosis, or hypersensitivity to their components. Genuine allergic reactions to liothyronine are extremely rare.

Medical Considerations

Individuals often use thyroid hormones for weight loss, usually alongside other substances. Therapeutic doses tend to be ineffective for weight loss, necessitating much larger amounts which can be hazardous, especially when combined with stimulants like ephedrine.

Specific conditions, such as adrenal insufficiency or diabetes, require careful monitoring and dosage adjustments. Thyroid hormones increase sensitivity to anticoagulants, raising bleeding risks. Claims of efficacy for infertility lack scientific backing.

Individuals with cardiovascular issues should consult a physician before initiating treatment, ensuring the lowest effective dose is prescribed.

Levels

Thyroid hormone levels can be efficiently monitored, as sporting organizations like the IOC and WADA routinely test athletes for thyroid hormones using highly sensitive assays.

Drug Interactions

Liothyronine interacts with various medications, including:

• Oral anticoagulants
• Insulin or other hypoglycemics
• Cholestyramine
• Estrogen, oral contraceptives
• Tricyclic antidepressants
• Digitalis

Physicians must ensure appropriate dosage to avoid adverse effects and patients should have regular follow-ups.

Treatment of Overdosage

In cases of suspected overdose, hospitalization is essential. Liothyronine treatment should be halted, with supportive care provided. Recovery may necessitate stopping the hormone for 4-8 weeks. Inducing vomiting is not advisable due to aspiration risks. Severe cases may require beta-adrenergic blockers to mitigate sympathetic effects.

Dosage

Liothyronine is prescribed as a daily tablet, with dosage tailored to hypothyroidism severity. Treatment should commence with the lowest possible dose due to rapid action onset; starting at 5 mcg/day, increased cautiously. Excessive dosing can exacerbate heart issues, with 50-75 mcg/day generally sufficient. Intravenous forms are available for emergencies like myxedema coma, a severe hypothyroidism complication, predominantly affecting elderly women.

Liothyronine comes in 5, 25, and 50 mcg tablets and requires a physician’s prescription in the US.