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Sildenafil

Viagra is a well-known medication that is categorized as a phosphodiesterase type 5 (PDE5) inhibitor.

Below are key details about Sildenafil:

Mechanism of Action

• Sildenafil inhibits the enzyme phosphodiesterase type 5 (PDE5), preventing the breakdown of cyclic guanosine monophosphate (cGMP). This increases cGMP levels during sexual stimulation, resulting in relaxed smooth muscles of blood vessels and enhanced blood flow to the penis.
• This process facilitates the attainment and maintenance of an erection.

Indications

• The primary use of Sildenafil is to address erectile dysfunction in men.
• It may also be utilized for treating arterial hypertension, sold under the name Revatio.

Onset of Action

• Sildenafil typically begins to work in about 30 minutes after ingestion, although some individuals may experience effects after up to 1 hour.

Duration of Action

• The effects of Sildenafil last approximately 4 to 5 hours, allowing ample time to achieve and hold an erection.

Dosage

• The standard starting dosage for Sildenafil is 50 mg, adjustable based on individual response.
• This dose should be taken around 30 minutes to 1 hour before planned sexual activity.

Side Effects

• Common adverse effects of Sildenafil may include headaches, facial flushing, indigestion, vision alterations, increased blood pressure, and in rare instances, hearing loss or changes.

Contraindications

• Sildenafil should not be combined with nitrates (e.g., nitroglycerin) due to the risk of a significant drop in blood pressure. It is strictly contraindicated in patients with notable heart conditions or those who have recently experienced a myocardial infarction or stroke.