Genesis Nandrolone Phenylpropionate Injection 10 amps (10x 100 mg/ml)

Nandrolone Phenylpropionate

Nandrolone phenylpropionate is a powerful injectable form of the anabolic steroid nandrolone. Its characteristics closely resemble those of Deca-Durabolin, which utilizes the longer-acting nandrolone decanoate. The key distinction lies in the release speed of nandrolone into the bloodstream. Nandrolone decanoate sustains a release lasting around three weeks, while nandrolone phenylpropionate remains effective for approximately one week. In clinical settings, Deca-Durabolin can be administered every 2 to 3 weeks, whereas Durabolin requires more frequent injections, typically every few days to weekly. Both drugs are interchangeable, with Deca-Durabolin being favored by athletes and bodybuilders for its ability to enhance strength and lean muscle mass gains with minimal estrogenic or androgenic side effects.

Structural Characteristics

Nandrolone decanoate is a modified nandrolone variant, incorporating a carboxylic acid ester (propionic phenyl ester) at the 17-beta hydroxyl position. Esterified steroids display reduced polarity compared to their non-esterified counterparts and are gradually absorbed post-injection. Once in the bloodstream, the ester is cleaved, resulting in active nandrolone. These modifications extend the therapeutic window, allowing less frequent injections compared to free steroids. Nandrolone phenylpropionate triggers a significant rise in nandrolone levels within 24-48 hours after deep intramuscular injection, gradually declining to baseline within a week.

Side Effects (Estrogenic)

Nandrolone exhibits a low propensity for estrogen conversion, only about 20% of that associated with testosterone. The liver can convert nandrolone to estradiol; however, in sites like adipose tissue, nandrolone is less responsive. Thus, estrogen-related side effects are not a significant concern with this drug compared to testosterone. Higher dosages may still elevate estrogen levels, leading to side effects including water retention, increased body fat, and gynecomastia. An anti-estrogen, such as clomiphene citrate or tamoxifen citrate, may be required to mitigate these effects. Alternatively, aromatase inhibitors like Arimidex (anastrozole) can effectively manage estrogen by inhibiting its production but may be costly and adversely affect blood lipids. Nandrolone also possesses progestin-like activity in the body. The removal of the c-19 group in 19-norprogesterone enhances its binding affinity to progesterone receptors. Consequently, many 19-nor anabolic steroids show some affinity for these receptors. Side effects akin to those of estrogen may occur, such as inhibiting testosterone production and increasing fat storage. The synergy between progestins and estrogens can also facilitate gynecomastia, even in the presence of normal estrogen levels. Using an anti-estrogen to suppress the estrogenic component is often enough to alleviate gynecomastia caused by nandrolone.

Side Effects (Androgenic)

Despite being categorized as an anabolic steroid, androgenic side effects can occur, particularly at higher doses. This includes oily skin, acne, and increased body or facial hair. Anabolic/androgenic steroids might exacerbate male pattern baldness. Women need to tread carefully due to potential virilizing effects, which may lead to voice deepening, menstrual irregularities, altered skin texture, facial hair growth, and clitoral enlargement. Nandrolone has relatively low androgenic activity compared to its muscle-building effects, hence the threshold for pronounced androgenic side effects is higher than with steroids like testosterone or methandrostenolone. It’s important to note that nandrolone may suppress libido in males if not paired with another androgen. In androgen-responsive tissues such as the skin and prostate, nandrolone’s androgenicity is diminished through conversion to dihydronandrolone (DHN) via the 5-alpha reductase enzyme. Concurrent use of a 5-alpha reductase inhibitor like finasteride may hinder this site-specific reduction, increasing the potential for androgenic effects. To maintain low androgenicity, it is advised to avoid reductase inhibitors when using nandrolone.

Side Effects (Hepatotoxicity)

Nandrolone is not C-17 alpha alkylated and is not known to induce hepatotoxic effects in healthy subjects, making liver toxicity highly unlikely.

Side Effects (Cardiovascular)

Anabolic/androgenic steroids may adversely alter serum cholesterol levels, lowering HDL (good) cholesterol while raising LDL (bad) cholesterol, contributing to a greater risk of arteriosclerosis. The impact on serum lipids varies with dosage, route of administration (oral vs. injectable), steroid type (aromatizable or non-aromatizable), and resistance to hepatic metabolism. Research found a 26% reduction in HDL among subjects taking 600mg of nandrolone decanoate weekly for 10 weeks, slightly exceeding reductions seen with the same dosage of testosterone enanthate. It’s worth noting that nandrolone decanoate poses a lesser threat to serum lipids compared to C-17 alpha alkylated agents. Additionally, anabolic/androgenic steroids may impact blood pressure and triglycerides, hinder endothelial relaxation, and promote left ventricular hypertrophy, heightening the risk of cardiovascular issues and myocardial infarction.

Side Effects (Testosterone Suppression)

All anabolic/androgenic steroids, when administered at doses conducive to muscle gain, are expected to suppress natural testosterone production. Studies involving 100mg of nandrolone decanoate weekly for 6 weeks revealed a 57% reduction in serum testosterone. At 300mg per week, the reduction reached 70%. It is believed that nandrolone’s progestational activity significantly contributes to this suppression of testosterone synthesis, despite its low capacity for estrogen conversion. Without interventions to stimulate testosterone, levels may normalize within 2 to 6 months post-therapy. However, prolonged hypogonadotrophic hypogonadism may arise from steroid abuse, necessitating medical intervention.

Administration (Men)

For general anabolic properties, early guidelines suggested administering 25 to 50mg weekly for 12 weeks. In pursuit of physique or performance enhancement, typical dosages range from 200 to 400mg weekly, taken in cycles lasting between 8 to 12 weeks. This dosage ensures most users achieve substantial gains in lean muscle and strength. Given the fast-acting nature of the phenylpropionate ester, these dosages are typically divided into two separate, evenly spaced applications weekly.

Administration (Women)

For general anabolic results, early guidelines indicated a dosage of 25 to 50mg weekly for 12 weeks. For physique or performance enhancement, a common dosage is 50mg weekly (typically via a single injection), used for cycles lasting 4 to 6 weeks. Caution is advised, as higher doses or extended use may precipitate androgenic side effects. Despite its relatively mild androgenic profile, women may experience virilization symptoms from this compound. Should such symptoms arise, immediate discontinuation of nandrolone phenylpropionate is essential to prevent irreversible changes.