Hubei Clomid 30 tabs (50 mg/tab) EXPIRATION

Clomiphene Citrate – Clomid

Clomiphene citrate, known as Clomid, is a powerful synthetic non-steroidal medication closely resembling estrogen. It’s predominantly utilized as an ovulatory stimulant. Due to its structural similarity to estrogen, Clomid effectively binds to estrogen receptors in the hypothalamus, preventing it from recognizing true estrogen levels. This action prompts the hypothalamus to stimulate the pituitary gland to release increased amounts of Gonadotropins, specifically FSH and LH, which in turn stimulate ovarian or testicular functions to produce more estrogen or testosterone.

Clomiphene is extensively used to assist women with ovarian failure and to induce ovulation. Nonetheless, prolonged use may heighten the risk of ovarian cancer.

Pharmacology

Clomid is recommended for women experiencing ovulatory dysfunction. Various women struggling to conceive often exhibit irregularities in their ovulation cycles. This includes conditions like polycystic ovarian syndrome and those with unexplained amenorrhea. Clomid prescriptions follow an extensive menstrual cycle evaluation to pinpoint the issue. Achieving ovulation with Clomid necessitates precise timing, involving monitoring basal body temperature and conducting blood tests to confirm ovulation occurrence.

Clomid is typically initiated around the 5th day of the menstrual cycle, administered for 3-6 cycles, as long-term treatment is generally discouraged.

Mode of Action

This potent drug aids infertile women when utilized with appropriate dosing and for short durations. Clomiphene’s estrogen-mimicking property allows it to interact with estrogen receptors in the hypothalamus, leading the brain to perceive low estrone levels. Consequently, Gonadotropin levels surge, stimulating the ovaries to enhance estrogen production. This estrogen spike is vital for successful fertilization.

Indications

Clomid is specifically designated for women with ovulatory dysfunction who also meet specific conditions:

• not pregnant during treatment
• absence of ovarian cysts, confirmed via ultrasound
• no vaginal bleeding, requiring thorough examination for cancer signs
• normal liver function tests
• while showing success in female infertility, Clomid’s efficacy in male infertility is less established; limited cases in Europe and the USA indicate increases in LH, FSH, and sperm count with short-term Clomid use, though there might be concerns of testicular tumors and mild gynecomastia
• prescription dosage for infertility

Clomiphene, a large molecule soluble in various organic solvents, is available in 50 mg tablets. Prior to treatment, patients must undergo comprehensive evaluations for gynecological and endocrine disorders. Ovulation generally occurs 5-10 days post-Clomid initiation, necessitating timed intercourse to coincide with ovulation.

Initially, Clomid is prescribed at 50 mg/day for 5 days, with dose adjustments available for those who do not ovulate.

Body Building

Clomid sees prevalent misuse among both amateur and professional athletes, often in conjunction with substances like anabolic steroids, HCG, and thyroid hormones. Unlike traditional anabolic steroids, Clomid enhances testosterone levels by inducing LH surges without suppressing testosterone itself.

Anabolic steroids typically possess both androgenic and anabolic traits, and some may exhibit mild estrogenic effects. The conversion of some anabolic steroids into estrogen can lead to gynecomastia. Clomid addresses this issue by blocking estrogen receptor activity, mitigating gynecomastia’s onset in bodybuilders. Additionally, Clomid’s action on estrogen receptors in the brain prompts LH and FSH surges, resulting in elevated testosterone synthesis, offering athletes an added performance edge.

Some bodybuilders utilize Clomid solely for its anabolic benefits, while others combine it with various steroids and growth hormones.

Clomid Dosage for Athletes

This medication is taken once daily. Bodybuilding experts recommend using Clomid alone or alongside low-potency anabolic steroids. Many bodybuilders cycle anabolic steroids for several months before switching to Clomid, leveraging its testosterone surge while preventing breast enlargement. The optimal timing for Clomid initiation remains uncertain, but it’s generally advised to start within 7-10 days after ceasing steroid use.

The dosage among athletes varies widely, with many taking 50-100 mg/day for two weeks. Increased doses to 100 mg/day are suggested if initial effects remain elusive. Cycling Clomid should conclude after three weeks. Given that no medical professionals endorse Clomid for bodybuilding, obtaining accurate medical guidance may be challenging. It’s wise to consult fertility specialists for expertise regarding this medication.

The precise duration for Clomid usage lacks clarity due to insufficient long-term data, and prolonged use is generally discouraged.

Side effects

When taken at recommended dosages for limited periods, Clomid is generally safe. The majority of side effects are transient and resolve upon treatment cessation.

• flushing
• abdominal discomfort
• nausea, vomiting
• breast tenderness
• headaches
• abnormal vaginal bleeding
• general fatigue
• hair loss
• visual disturbances

The primary concern arises from Clomid’s impact on the brain. By inhibiting estrogen receptors in the hypothalamus, Clomid triggers the release of stimulating factors, leading to pituitary hyperstimulation and potential nerve compression affecting vision. Numerous documented cases report visual disturbances after long-term Clomid use, with some individuals experiencing issues after a mere 7-10 days. Issues may arise spontaneously, making activities like driving hazardous. Most visual problems reverse upon discontinuation of Clomid; immediate cessation and an ophthalmology consultation are advised upon noticing vision changes.

Mood changes

Another significant side effect includes mood alterations. Reports indicate that women on Clomid for extensive periods may encounter behavioral issues, including severe depression, anxiety, aggression, paranoia, restlessness, and insomnia.

Despite these potential side effects, less than 1% of women participating in clinical studies reported them, and specific data on bodybuilding-related side effects is unclear.

Cost

While a physician’s prescription is required for using Clomid in infertility treatment, it is readily available online without one. The price of clomiphene varies, with an average cost of $50-$100 for 100 pills (25-50 mg).

Levels

Clomiphene is accessible for anyone interested in its use. However, all professional sports organizations prohibit its use, identifying it in urine for 5-12 days post-use. Advanced testing can measure testosterone and estrogen levels and their ratios, indicating possible abuse.