Sandoz Omnitrope SurePal 5 vials (5x 15 IU)

HGH – human growth hormone

Human growth hormone is a vital hormone secreted by the anterior pituitary gland, playing a crucial role in growth and development. Growth hormone (GH) levels peak in late adolescence and begin to decrease by the age of 20. Over 40 years ago, GH became available for treating specific medical disorders. Recently, a surge in interest has led to widespread use among middle-aged individuals seeking anti-aging benefits, teenagers desiring physical enhancement, and athletes aiming for improved performance, making it one of the three most abused substances in sports.

What is Human Growth Hormone?

Human growth hormone, referred to as hGH or GH, activates cell production and metabolic processes in the body. Produced by the anterior pituitary, GH works with other hormones to regulate growth and development, peaking at puberty and declining around 40.

Growth hormone is available from health food stores, spas, and alternative practitioners under various brand names like Genotropin®, Humatrope®, and Norditropin®.

Pharmacology

The majority of available GH is produced via recombinant DNA technology, primarily as somatropin and somatrem. Both forms exhibit identical pharmacological effects, binding to GH receptors to stimulate cellular actions. GH influences metabolism, fluid balance, and increases muscle and bone mass, with higher levels during stress, sleep, and exercise.

When do GH levels change?

Changes in GH levels can lead to medical conditions. Excess levels may result in acromegaly, characterized by abnormal growth, or pituitary gigantism, while deficiencies can lead to serious health problems, including short stature.

FDA Approved Clinical Uses of GH

The FDA has authorized several preparations of HGH, requiring a prescription. Initially approved in 1985 for GH deficiency, it’s now also approved for conditions like Prader-Willi syndrome and Turner syndrome. Clinical evidence suggests GH therapy can enhance muscle mass, reduce fat, improve cognitive function, and enhance exercise performance.

• Increased muscle mass and bone density
• Decreased body fat
• Improved cognitive function
• Enhanced exercise performance
• Greater cardiovascular resilience

Dosage

GH is administered via injection only, either subcutaneous or intramuscularly, with dosing based on IGF levels or body weight (approximately 0.01-0.1 mg/kg). It is available as both powder and liquid, requiring solubilization in saline before administration.

Potential Side Effects of Growth Hormone

Common side effects of GH may include:

• Generalized edema
• Carpal tunnel syndrome
• Joint and muscle pain
• Nerve pain (e.g., tingling)
• Elevated blood glucose levels

Is a Prescription Required for GH?

GH is legally prescribed only for FDA-approved conditions, but it’s often misused for off-label purposes, including athletic enhancement and anti-aging therapies. While some advocate for its benefits, the associated risks warrant caution.

Potential Risks of Taking GH

GH carries risk of overdose and complications like acromegaly or cancer proliferation. Less severe side effects could involve fluid retention, carpal tunnel syndrome, and type 2 diabetes. Those considering GH therapy for anti-aging should carefully evaluate its risks versus benefits.

Off-Label Use

Bodybuilding

The primary off-label uses include anti-aging and bodybuilding, with GH being notably abused in athletic circles. Costs for bodybuilding can range from $500 to $2000 monthly, often with risks of counterfeit products.

Anti-Aging

GH is sought for cosmetic rejuvenation; however, it has not been approved for anti-aging treatments, with no credible evidence supporting its efficacy in altering skin appearance.

Availability

Many acquire HGH illegally, whether through theft, unethical prescribing, or online pharmacies, which usually lack proper medical protocols.

Testing Limitations

Synthetic GH is challenging to detect post-injection; current methods can typically identify it only within 48 hours, giving athletes an advantage.

Sermorelin

Sermorelin, a GHRH analog, stimulates GH production without being detectable in urine or blood after a specific period. It is designed mainly for the aging population but isn’t a substitute for GH.

Control Status

The misuse of GH has led to federal regulations. Under the Anabolic Steroids Control Act, unauthorized possession or distribution can incur serious legal penalties. GH is classified as a performance-enhancing substance by major sports organizations.