Sopharma Tamoxifen 30 tabs (10 mg/tab)

Tamoxifen – Nolvadex

Nolvadex, a non-steroidal medication, is renowned for its powerful anti-estrogen effects. By attaching to estrogen receptors, it effectively inhibits estrogen action. It’s primarily indicated for treating specific breast cancer types in both women and men. Additionally, Nolvadex serves as a preventive measure for women at high risk of developing breast cancer post ductal carcinoma in situ. Ongoing research is exploring its potential in treating other breast cancer variants. Known as tamoxifen citrate, it maintains versatility in oncology treatments.

Indications

Nolvadex is instrumental in managing metastatic breast cancer in both genders, specifically benefiting premenopausal women as an alternative to surgical interventions or radiation therapy. Its efficacy is highest in patients with estrogen receptor-positive tumors, also recommended as adjuvant therapy for women post-surgery.

Dosage

Nolvadex is available in 10/20 mg tablets and a 10 mg solution. The standard dosage is 20 mg daily, taken orally and readily absorbed, with or without food. For breast cancer patients, doses typically range from 20-40 mg/day, with higher amounts divided into 1-3 doses. Bodybuilders usually start with 20 mg/day, increasing to 30 mg/day as needed, but long-term therapy beyond 5 years isn’t advised.

Bodybuilders

While Nolvadex itself exhibits no direct anabolic or androgenic properties, its ability to block estrogen receptors results in secondary benefits. By inhibiting estrogen on the hypothalamus, it triggers increased gonadotropins (LH and FSH), stimulating sex hormone production and leading to enhanced testosterone synthesis. Many bodybuilders use Nolvadex after anabolic steroid cycles to counteract testosterone suppression, with it often preferred over Arimidex for preventing gynecomastia and water retention during washout periods, maintaining weight gains while allowing testicular recovery.

Women

Nolvadex is frequently prescribed for women diagnosed with metastatic breast cancer, necessitating regular medical follow-ups for all users, especially those bodybuilding. Side effects warranting attention include:

• vaginal bleeding
• new breast lumps
• lower abdominal fullness
• pelvic pain
• leg swelling
• shortness of breath
• vision changes
• irregular menstrual cycles

Regular breast examinations are crucial for all women taking Nolvadex, especially since it may diminish the effectiveness of birth control pills.

Overall side effects

Nolvadex boasts a strong safety profile, with significant side effects occurring in less than 1-3% of users, leading to minimal discontinuation rates. Commonly reported side effects include:

• hot flashes
• leg swelling
• altered taste
• genital itching
• depression
• dizziness
• headaches
• hair loss
• vaginal dryness
• nausea and vomiting
• bone pain
• coughing
• abdominal cramps
• loss of appetite

Most side effects subside upon discontinuation of therapy.

Warnings

Caution is advised with Nolvadex, as it may induce hypercalcemia and has been associated with increased uterine cancer risks. Blood clotting issues leading to pulmonary embolism are also noted alongside rare complications like liver cancer and vision changes.

Overdose

Nolvadex is well-tolerated, with no overdose cases on record. In instances of high intake, symptoms may not surface for 4-6 days, potentially leading to tremors, dizziness, or irregular heart rates; supportive treatment is recommended, with no lasting toxicity expected.

Detection

Many sports organizations actively screen for Nolvadex. While female users with prescriptions may proceed, males detected with this substance face disqualification from sports competitions. Detection of Nolvadex and its metabolites can last 3-4 weeks post-last dosage.

Cost

Nolvadex is widely accessible, though costs vary, averaging $1.50-$2.00 per pill. Generic versions from Asia are cheaper but their purity and quality may be uncertain. Currently, no counterfeit Nolvadex products are reported on the market.