Sunrise Malegra DXT 10 tabs (100 + 30 mg/tab)

Sildenafil

Sildenafil is a potent medication categorized under phosphodiesterase type 5 (PDE5) inhibitors, commonly recognized by its brand name, Viagra.

Discover the key characteristics of Sildenafil:

Mechanism of Action

• Sildenafil inhibits the enzyme phosphodiesterase type 5 (PDE5), preventing the breakdown of cyclic guanosine monophosphate (cGMP), which enhances blood flow to the penis during sexual arousal.
• This facilitates erection achievement and maintenance.

Indications

• This medication is primarily indicated for treating erectile dysfunction in men.
• Additionally, it is utilized to manage pulmonary arterial hypertension under the name Revatio.

Onset of Action

• Expect action onset within 30 minutes post-ingestion, although some individuals may experience effects after up to 1 hour.

Duration of Action

• The therapeutic effects typically persist for 4 to 5 hours, enabling effective and sustained erections.

Dosage

• A common starting dosage for Sildenafil is 50 mg, adjustable based on individual response.
• It is advisable to take the dose approximately 30 minutes to 1 hour before sexual activity.

Side Effects

• Frequent side effects include headache, facial flushing, indigestion, vision alterations, increased blood pressure, and in rare cases, hearing disturbances.

Contraindications

• Avoid co-administration with nitrates (like nitroglycerin) due to the risk of significant blood pressure reduction, and it is contraindicated in individuals with serious heart conditions or recent cardiovascular events.

Duloxetine

Duloxetine is an effective medication classified as a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) and is marketed as Cymbalta.

Explore the primary attributes of duloxetine:

Mechanism of Action

• This medication influences the central nervous system by boosting serotonin and norepinephrine levels, enhancing mood and alleviating pain.

Indications

• Approved for managing depressive disorders.
• Used for Generalized Anxiety Disorder (GAD).
• Treats neuropathic pain including diabetic peripheral neuropathy and fibromyalgia.
• Also prescribed for chronic pain related to chronic back conditions.

Onset of Action

• While duloxetine’s full effects may take weeks in depression treatment, it may act quicker for anxiety and pain in some patients.

Dosage

• Duloxetine generally starts at low doses which are progressively increased based on the patient’s response, typically ranging from 40 to 60 mg daily for depression.
• For pain management, 60 mg daily is commonly effective.

Side Effects

• Common adverse effects encompass hot flashes, dry mouth, gastrointestinal changes, insomnia or drowsiness, appetite loss, headaches, heightened anxiety, and decreased libido.

Contraindications

• Not recommended for individuals with specific liver conditions or those taking monoamine oxidase inhibitors (MAOIs).
• Caution is advised for pregnant women, particularly during late pregnancy.