Swiss Healthcare T3+T4 – Liothyronine + Levothyroxine 60 tabs (30 + 120 mcg/tab)

Liothyronine – Cytomel

Thyroid hormones, essential for metabolism, are naturally produced by the body. Due to their simple molecular structure, many pharmaceutical companies offer synthetic versions of these hormones. The primary thyroid hormones include T4 (levothyroxine) and T3 (liothyronine), both synthesized and stored in the thyroid gland.

The synthesis of thyroid hormones by pharmaceutical firms occurs through two methods: either derived from animal thyroid glands (bovine or ovine) or synthetically produced. In the USA, iodine content in thyroid preparations is tightly regulated.

Cytomel (liothyronine sodium) is available in tablet form and as a naturally occurring thyroid hormone salt. Notably, T3 is significantly more potent than T4.

Pharmacology

The precise mechanism of how thyroid hormones function remains unclear, but their effects involve complex biochemical changes within cells, primarily providing energy. They boost the consumption of carbohydrates, lipids, and proteins while increasing oxygen uptake, leading to a higher basal metabolic rate. The influence of these hormones extends to virtually every organ, including the brain, highlighting their critical role, especially for those deficient in thyroid hormones.

Dosage

Thyroid hormones are rapidly absorbed from the gastrointestinal tract into the bloodstream, with effects typically beginning within hours, although peak activity may take several days. The hormone remains active in the body for days due to binding with albumin, protecting it from hepatic breakdown.

• Used as replacement therapy for hypothyroidism.
• Provided for patients post-thyroidectomy.
• Indicated for goiters and thyroid nodules.
• Serves as a diagnostic tool in suppression tests for suspected hyperthyroidism.
• Cytomel is an option for those allergic to pork or beef thyroid preparations.

Body Builders and Weight Loss

Thyroid hormones, including Cytomel, have been misused by athletes for weight loss due to their ability to combust fats and carbohydrates. This widespread use spans various sports, with athletes taking the hormone for 4-6 weeks, halting it before competitions. While many report effective weight loss and enhanced energy, the situation is complicated by concurrent use of other supplements and hormones.

Online sellers often recommend initiating Cytomel therapy at 25 mcg/day, increasing it by 5-10 mcg/day over weeks. The maximum tolerated dose without side effects is around 100 mcg/day. Users must understand that cessation of the drug could result in thyroid insufficiency due to hormonal suppression, necessitating a gradual reduction in dosage to allow thyroid function to resume.

Consultation with a physician is highly advised for anyone considering thyroid hormone use for off-label purposes such as weight loss.

Signs and Symptoms

Excessive thyroid hormone can induce a variety of side effects, including:

• Headaches
• Altered mood: irritability, anxiety
• Sweating
• Abnormal heart rhythms
• Palpitations
• Chest pain
• Diarrhea
• Menstrual irregularities
• Worsening heart failure
• Shock

Severe overdoses can mimic symptoms of a thyroid storm, while chronic overconsumption may lead to hyperthyroidism symptoms.

Contraindications

Liothyronine should be avoided in patients with untreated adrenal insufficiency, thyrotoxicosis, or known allergies to its components. True allergic reactions to liothyronine are considered rare.

Signs and Symptoms

Individuals often misuse thyroid hormones for weight loss, commonly combining them with other supplements. Therapeutic doses typically yield minimal weight loss, necessitating larger yet potentially dangerous doses that can exacerbate symptoms when used with other agents like ephedrine or growth hormone.

Caution is warranted for those with specific medical conditions, as thyroid hormone usage can worsen adrenal insufficiency and impact diabetes management. Additionally, it may enhance sensitivity to anticoagulants, elevating bleeding risks.

Although frequently suggested by non-medical professionals for infertility, there is no scientific basis for thyroid hormones benefiting infertility treatment.

Thyroid hormones are not without risks and can cause serious side effects; thus, individuals with heart issues should consult their physicians before beginning therapy.

Levels

Thyroid hormone levels can be easily monitored, with sporting organizations like the IOC and WADA routinely screening athletes for these substances. Available radioimmunoassays can detect minute levels in urine.

Drug Interactions

Liothyronine may interact with several medications, including:

• Oral anticoagulants
• Insulin or oral hypoglycemics
• Cholestyramine
• Estrogen, oral contraceptives
• Tricyclic antidepressants
• Digitalis

Prescribing physicians should closely monitor thyroid hormone doses to avoid excess, with regular patient follow-ups being crucial.

Treatment of Overdosage

In cases of suspected thyroid hormone overdose, immediate hospital admission is necessary. The hormone should be discontinued temporarily, and the patient monitored closely. Overdose typically requires cessation of the hormone for 4-8 weeks for recovery of thyroid function; no specific antidote exists. Supportive care is vital, with measures such as avoiding induced vomiting due to aspiration risks. Severe cases may necessitate temporary mechanical ventilation in an ICU setting, while most require fluid resuscitation and oxygen supplementation.

Dosage

Liothyronine is taken orally once daily, with dosage adjusted according to the level of hypothyroidism. Treatment should commence with the lowest effective dose, starting at 5 mcg/day, increased gradually by no more than 5 mcg every 2-3 weeks. High initial doses can exacerbate heart conditions. Common therapeutic levels range from 50 to 75 mcg/day. Injectable formulations of liothyronine can also be used for severe cases like myxedema coma, primarily observed in elderly women.

Liothyronine is available in 5, 25, and 50 mcg tablets. A doctor’s prescription is mandatory for obtaining this medication in the USA.

T4 – Liothyronine Sodium

T4 is a synthetic thyroid hormone primarily utilized in treating hypothyroidism. This synthetic variant of T4 hormones enhances central nervous system function, promotes fat burn, and supports overall wellness.

Dosage

Usual dosage ranges from 100 to 300 mcg daily.

Effects

Athletes frequently use T4 to enhance physical performance and facilitate weight loss without experiencing hunger.

Side Effects

Common side effects associated with T4 include insomnia, tremors, anxiety, irregular heartbeat, and suppression of natural thyroid hormone production.

Protection

To mitigate side effects, consider adding beta-adrenoblockers and ketotifen into your regimen. Using T4 in the mornings can help reduce insomnia incidence.

Stacking

When stacking T4 with other medications impacting blood pressure and heart rate, exercise extra caution.